Human Cytochrome P450 26A1, CYP26A1 ELI
3,140.00 ₪
A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription.
Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18.
Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers (PubMed: 22020119, PubMed: 9228017, PubMed: 9716180).
May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed: 26937021).
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