Human Cytochrome P450 2C19, CYP2C19 ELI

A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) (PubMed: 18577768, PubMed: 19965576, PubMed: 20972997).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed: 18577768, PubMed: 19965576, PubMed: 20972997).

Catalyzes the hydroxylation of carbon-hydrogen bonds.

Hydroxylates PUFA specifically at the omega-1 position (PubMed: 18577768).

Catalyzes the epoxidation of double bonds of PUFA (PubMed: 20972997, PubMed: 19965576).

Also metabolizes plant monoterpenes such as limonene.

Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed: 11950794).

Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.

Hydroxylates fenbendazole at the 4' position (PubMed: 23959307).