Human Cytochrome P450 2E1, CYP2E1 ELI

A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed: 10553002, PubMed: 18577768).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed: 10553002, PubMed: 18577768).

Catalyzes the hydroxylation of carbon-hydrogen bonds.

Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids (PubMed: 10553002, PubMed: 18577768).

May be involved in the oxidative metabolism of xenobiotics (Probable).