Human Cytokeratin 10,CK-10 ELI

Plays a role in the establishment of the epidermal barrier on plantar skin.

{ECO:0000250|UniProtKB:P02535}.; (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.

{ECO:0000269|PubMed:15385531}.; (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines.

Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence.

Neither protein has to be glycosylated for the interaction to occur.

{ECO:0000269|PubMed:19627498}.