Human Cytoplasmic Aconitate Hydratase, ACO1 ELI

Iron sensor.

Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high.

Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low.

Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low.

Binding of a 4Fe-4S cluster precludes RNA binding.

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.