Human Dedicator of Cytokinesis Protein 1, DOCK1 ELI

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility.

Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed: 19004829).

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP.

Its GEF activity may be enhanced by ELMO1 (PubMed: 8657152).