Human Defensin Beta 114,DEFb114 ELI

Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans.

Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS.

Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality.

{ECO:0000269|PubMed:23482568}.