Human Deleted In Malignant Brain Tumors 1, DMBT1 ELI

May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers.

May play roles in mucosal defense system, cellular immune defense and epithelial differentiation.

May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract.

May play a role in liver regeneration.

May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage.

Required for terminal differentiation of columnar epithelial cells during early embryogenesis.

May function as a binding protein in saliva for the regulation of taste sensation.

Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission.

Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens.

Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity.

Inhibits cytoinvasion of S.enterica.

Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis.

Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.