Human Diacylglycerol-O-Acyltransferase Homolog 1, DGAT1 ELI

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed: 16214399, PubMed: 18768481, PubMed: 28420705, PubMed: 9756920, PubMed: 32433611, PubMed: 32433610).

Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (PubMed: 18768481).

In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed: 16214399).

Also present in female mammary glands, where it produces fat in the milk (By similarity).

May be involved in VLDL (very low density lipoprotein) assembly (PubMed: 18768481).

In contrast to DGAT2 it is not essential for survival (By similarity).

Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed: 16214399).

Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester Synthases (By similarity).

Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed: 28420705).