Human Dickkopf-Related Protein 1, DKK1 Primacu™ ELI

Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6.

DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6.

Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos.

DKK-1 protein modulates Wnt signaling pathway during embryonic development.

Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.