Human Dipeptidase 1, DPEP1 ELI

Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 (PubMed: 2303490, PubMed: 6334084, PubMed: 31442408).

Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (By similarity).

Possesses also beta lactamase activity and hydrolytically inactivates beta-lactam antibiotics (PubMed: 6334084).

Independently of its dipeptidase activity acts as an adhesion receptor for neutrophils recruitement from bloodstream into inflammed lungs and liver.