Human DNA-binding Protein Ikaros, IKZF1 ELI

Transcription regulator of hematopoietic cell differentiation (PubMed: 17934067).

Binds gamma-satellite DNA (PubMed: 17135265, PubMed: 19141594).

Plays a role in the development of lymphocytes, B- and T-cells.

Binds and activates the enhancer (delta-A element) of the CD3-delta gene.

Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation.

Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes.

Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes.

Increases normal apoptosis in adult erythroid cells.

Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity).

Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed: 17135265, PubMed: 17934067).