Human DNA (cytosine-5)-methyltransferase 3A,DNMT3A ELI

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443).

DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443).

It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443).

May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity).

Plays a role in paternal and maternal imprinting (By similarity).

Required for methylation of most imprinted loci in germ cells (By similarity).

Acts as a transcriptional corepressor for ZBTB18 (By similarity).

Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity).

Can actively repress transcription through the recruitment of HDAC activity (By similarity).

Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity).

{ECO:0000250|UniProtKB:O88508, ECO:0000269|PubMed:12138111, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}.