Human Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A,DYRK1A ELI
3,140.00 ₪
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities.
May play a role in a signaling pathway regulating nuclear functions of cell proliferation.
Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity).
Exhibits a substrate preference for proline at position P+1 and arginine at position P-3.
Has pro-survival function and negatively regulates the apoptotic process.
Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1.
This in turn inhibits TP53 activity and apoptosis (By similarity).
{ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q9NR20, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.
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