Human Dystroglycan 1 (dystrophin-associated glycoprotein 1),DAG1 ELI

The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; [Alpha-dystroglycan]: Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.

Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells.

Also acts as a receptor for laminin LAMA5 (By similarity).

{ECO:0000250|UniProtKB:O18738}.; [Beta-dystroglycan]: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton.

Acts as a cell adhesion receptor in both muscle and non-muscle tissues.

Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton.

Also functions in cell adhesion-mediated signaling and implicated in cell polarity.; [Alpha-dystroglycan]: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses (PubMed:16254364, PubMed:19324387, PubMed:17360738).

Acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2 (PubMed:9851927).

{ECO:0000269|PubMed:16254364, ECO:0000269|PubMed:17360738, ECO:0000269|PubMed:19324387, ECO:0000269|PubMed:9851927}.