Human E3 ubiquitin-protein ligase NEDD4-like,NEDD4L ELI

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation.

Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338).

Promotes ubiquitination and degradation of SGK1 and TNK2.

Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046).

Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Involved in the regulation of TOR signaling (PubMed:27694961).

Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338).

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