Human E3 ubiquitin-protein ligase TRIM56,TRIM56 ELI
3,140.00 ₪
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118).
In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity).
Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling.
Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES.
Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
{ECO:0000250|UniProtKB:Q80VI1, ECO:0000269|PubMed:21289118, ECO:0000269|PubMed:22948160}.
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