Human Endonuclease G, Mitochondrial, ENDOG ELI

Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts.

In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities.

Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).