Human Endoplasmic Reticulum Aminopeptidase 1, ERAP1 ELI

Aminopeptidase that plays a central role in Peptide trimming, a step required for the generation of most HLA class I-binding Peptides.

Peptide trimming is essential to customize longer precursor Peptides to fit them to the correct length required for presentation on MHC class I molecules.

Strongly prefers substrates 9-16 residues long.

Rapidly degrades 13-mer to a 9-mer and then stops.

Preferentially hydrolyzes the residue Leu and Peptides with a hydrophobic C-terminus, while it has weak activity toward Peptides with charged C-terminus.

May play a role in the inactivation of Peptide hormones.

May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.