Human Erythropoietin Receptor, EPOR Primacu™ ELI

Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner.

The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR/EPO Receptor) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage.

EPOR protein is a type â… single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers.

EPOR signaling prevents neuronal death and ischemic injury.

Recent studies have shown that EPO and EPOR protein may be involved in carcinogenesis, angiogenesis, and invasion.