Human excision repair cross-complementation group 1,ERCC1 ELI

[Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair.

Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL).

Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure.

Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.

{ECO:0000269|PubMed:17273966, ECO:0000269|PubMed:23623389, ECO:0000269|PubMed:24036546}.; [Isoform 2]: Not functional in the nucleotide excision repair pathway.

{ECO:0000305|PubMed:24036546}.; [Isoform 3]: Not functional in the nucleotide excision repair pathway.

{ECO:0000305|PubMed:24036546}.; [Isoform 4]: Not functional in the nucleotide excision repair pathway.

{ECO:0000305|PubMed:24036546}.