Human Exosome Complex Component Rrp4, EXOSC2 ELI

Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene.

Mammalian mRNAs contain AU-rich elements (AREs) within their three prime untranslated regions.

In yeast, 3-prime-to-5-prime mRNA degradation is mediated by the exosome, a multisubunit particle.

EXOSC2 (which is homologous to the yeast Rrp4 protein) is a component of the human exosome.