Human Extracellular Sulfatase Sulf-1, SULF1 ELI

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity.

It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.

Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.