Human Fascin, FSCN1 ELI

Actin-binding protein that contains 2 major actin binding sites (PubMed: 21685497, PubMed: 23184945).

Organizes filamentous actin into parallel bundles (PubMed: 20393565, PubMed: 21685497, PubMed: 23184945).

Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed: 22155786).

Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed: 20393565, PubMed: 21685497, PubMed: 23184945).

Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed: 22155786).