Human Fermitin Family Homolog 3, FERMT3 ELI

Plays a central role in cell adhesion in hematopoietic cells (PubMed: 19234463, PubMed: 26359933).

Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity).

Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed: 19234460).

Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).

Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.