Human Fibroblast Growth Factor 2, FGF2 ELI

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed: 8663044).

Also acts as an integrin ligand which is required for FGF2 signaling (PubMed: 28302677).

Binds to integrin ITGAV:ITGB3 (PubMed: 28302677).

Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed: 8663044, PubMed: 28302677).

Functions as a potent mitogen in vitro (PubMed: 1721615, PubMed: 3964259, PubMed: 3732516).

Can induce angiogenesis (PubMed: 23469107, PubMed: 28302677).

Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed: 29501879).