Human Filamin A, FLNA ELI

Connects cell membrane constituents to the actin cytoskeleton.

May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins.

Anchors various transmembrane proteins to the actin cytoskeleton.

Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate.

Various interactions and localizations of isoforms affect myotube morphology and myogenesis.

Isoform 6 accelerates muscle differentiation in vitro.