Human Folate Receptor Alpha, FOLR1 ELI

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells.

Has high affinity for folate and folic acid analogs at neutral pH.

Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Required for normal embryonic development and normal cell proliferation.