Human Follistatin-related Protein 3, FSTL3 ELI

Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN.

Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B.

Involved in bone formation; inhibits osteoclast differentiationc.

Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma.

Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.