Human Formin-binding Protein 1-like, FNBP1L ELI

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis.

May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules.

Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells.

Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles.

Essential for autophagy of intracellular bacterial pathogens.