Human Fructosamine-3-kinase, FN3K ELI

Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed: 11016445, PubMed: 11522682, PubMed: 11975663).

Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (PubMed: 11522682, PubMed: 11975663).

Involved in intracellular deglycation in erythrocytes (PubMed: 11975663).

Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity).

Also able to phosphorylate psicosamines and ribulosamines (PubMed: 14633848).