Human G Protein Coupled Receptor 84, GPR84 ELI

Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14.

Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists.

Not activated by short-chain and long-chain saturated and unsaturated FFAs.

Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway.

May have important roles in processes from fatty acid metabolism to regulation of the immune system.