Human Gamma-secretase Subunit Aph-1A, APH1A ELI

Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed: 12297508, PubMed: 12522139, PubMed: 12763021, PubMed: 12679784, PubMed: 25043039, PubMed: 26280335, PubMed: 30598546, PubMed: 30630874).

Required for normal gamma-secretase assembly (PubMed: 12522139, PubMed: 12471034, PubMed: 12763021, PubMed: 19369254).

The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).