Human Gasdermin-A,GSDMA ELI

[Gasdermin-A]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death.

{ECO:0000269|PubMed:27281216}.; [Gasdermin-A, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:17471240, PubMed:27281216).

Released upon cleavage in vitro of genetically engineered GSDMA, and binds to membrane inner leaflet lipids (PubMed:27281216).

Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:27281216).

Binds to membrane inner leaflet lipids, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:27281216).

The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (PubMed:27281216).

{ECO:0000269|PubMed:17471240, ECO:0000269|PubMed:27281216}.