Human Gasdermin-C,GSDMC ELI

[Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death.

{ECO:0000250|UniProtKB:Q96QA5}.; [Gasdermin-C, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:27281216).

Released upon cleavage and binds to membrane inner leaflet lipids.

Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (By similarity).

The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown (Probable).

{ECO:0000250|UniProtKB:Q96QA5, ECO:0000269|PubMed:27281216, ECO:0000305}.