Human GATA binding protein 4,GATA4 ELI
3,140.00 ₪
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724).
In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724).
Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression.
Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity).
Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity).
Promotes cardiac myocyte enlargement (PubMed:20081228).
Required during testicular development (PubMed:21220346).
May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735).
{ECO:0000250|UniProtKB:P46152, ECO:0000250|UniProtKB:Q08369, ECO:0000269|PubMed:15734735, ECO:0000269|PubMed:20081228, ECO:0000269|PubMed:21220346, ECO:0000269|PubMed:24000169, ECO:0000269|PubMed:27984724}.
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