Human Glucagon-like Peptide 1 Receptor, GLP1R ELI

G-protein coupled receptor for glucagon-like Peptide 1 (GLP-1) (PubMed: 8405712, PubMed: 8216285, PubMed: 7517895, PubMed: 19861722, PubMed: 26308095, PubMed: 27196125, PubMed: 28514449).

Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed: 8405712, PubMed: 8216285, PubMed: 7517895, PubMed: 19861722, PubMed: 26308095, PubMed: 27196125, PubMed: 28514449).

Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).