Human Glucose transporter 4,GLUT4 ELI

Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation.

Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells.

Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.

{ECO:0000250|UniProtKB:P19357}.