Human Glutamate Carboxypeptidase 2, FOLH1 ELI

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity.

Has a preference for tri-alpha-glutamate Peptides.

In the intestine, required for the uptake of folate.

In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate.

Involved in prostate tumor progression.

Also exhibits a dipeptidyl-peptidase IV type activity.

In vitro, cleaves Gly-Pro-AMC.