Human Glutamate Cysteine Ligase Catalytic Subunit, GCLC ELI

Glutamate—cysteine ligase catalytic subunit is an enzyme that in humans is encoded by the GCLC gene.

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis.

The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit.

The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6.

The regulatory subunit is derived from a different gene located on chromosome 1p22-p21.

Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.