Human Glutamate Dehydrogenase 1, Mitochondrial, GLUD1 ELI

Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate.

Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed: 11032875, PubMed: 16959573, PubMed: 11254391, PubMed: 16023112).

Plays a role in insulin homeostasis (PubMed: 9571255, PubMed: 11297618).

May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).