Human Glutaminyl-peptide Cyclotransferase, QPCT ELI

Responsible for the biosynthesis of pyroglutamyl Peptides.

Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue.

Also catalyzes N-terminal pyroglutamate formation.

In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta Peptides [Glu-3]-amyloid-beta.

May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming Peptides.