Human Glutaredoxin 3, GLRX3 ELI

Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed: 26613676, PubMed: 27519415).

Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity).

Required for hemoglobin maturation (PubMed: 23615448).

Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.