Human Glycocalicin, GC ELI

Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects.

Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity.

Glycodelin-A has contraceptive and immunosuppressive activities (PubMed: 9918684, PubMed: 7531163).

Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed: 17192260).

Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed: 12672671).

Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed: 15883155).