Human Golgin Subfamily A Member 2, GOLGA2 ELI

Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed: 16489344).

Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity).

Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.

Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity).

Also plays a key role in spindle pole assembly and centrosome organization (PubMed: 26165940).

Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha.

TPX2 then activates AURKA kinase and stimulates local microtubule nucleation.

Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed: 19242490, PubMed: 26165940).

Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity).

Also regulates the centrosome organization (PubMed: 18045989, PubMed: 19109421).

Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed: 16489344, PubMed: 17314401).