Human Heat Shock Protein 90kDa Beta 1,HSP90b1 ELI
3,140.00 ₪
Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity).
When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity).
Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092).
Has ATPase activity (By similarity).
May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059).
{ECO:0000250|UniProtKB:P08113, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:32272059}.
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