Human Hematological and neurological expressed 1 protein,HN1 ELI

Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408).

Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422).

Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365).

Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).

{ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}.