Human Heparin Co Factor 2, HC2ELI

Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate.

In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III).

Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.

Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.