Human Hepatitis A Virus Cellular Receptor 1, HAVCR1 Primacu™ ELI

HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulin mucin 1 (TIM-1), is a type of integral membrane glycoprotein.

KIM-1 protein is widely expressed with the highest levels in the kidney and testis.

It has been shown to play a major role as a human susceptibility gene for asthma, allergy, and autoimmunity.

IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions.

KIM-1 involves in the pathogenesis of acute kidney injury.

It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker.

Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.