Human Hepatocyte nuclear factor 3-beta,FOXA2 ELI

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues.

Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites.

Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity).

In embryonic development is required for notochord formation.

Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles.

Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc.

Interacts with the cis-acting regulatory regions of these genes.

Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis.

Involved in regulation of fat metabolism.

Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

{ECO:0000250}.